Eva Pastalkova Hippocampus Internally Generated Cell Assembly

Supporting Online Material for Internally Generated Cell Assembly Sequences in the Rat Hippocampus

Internally generated cell assembly sequences in the rat hippocampus.

A long-standing conjecture in neuroscience is that aspects of cognition depend on the brain's ability to self-generate sequential neuronal activity. We found that reliably and continually changing cell assemblies in the rat hippocampus appeared not only during spatial navigation but also in the absence of changing environmental or body-derived inputs. During the delay period of a memory task, e...

Eva Pastalkova Hippocampus Internally Generated Cell Assembly Sequences in the Rat

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Cell assembly sequences arising from spike threshold adaptation keep track of time in the hippocampus.

Hippocampal neurons can display reliable and long-lasting sequences of transient firing patterns, even in the absence of changing external stimuli. We suggest that time-keeping is an important function of these sequences, and propose a network mechanism for their generation. We show that sequences of neuronal assemblies recorded from rat hippocampal CA1 pyramidal cells can reliably predict elap...

Storage of spatial information by the maintenance mechanism of LTP.

Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypic...